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7 October 2016

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  • Nkuipou-Kenfack E, Bhat A, Klein J, Jankowski V, Mullen W, Vlahou A, Dakna M, Koeck T1 Schanstra JP, Zürbig P, Rudolph KL, Schumacher B, Pich A, Mischak H., Identification of ageing-associated naturally occurring peptides in human urine., Oncotarget, 2015, Epub

  • Charmpilas N, Daskalaki I, Papandreou M, Tavernarakis N, Protein synthesis as an integral quality control mechanism during ageing., Ageing Res Rev. 23(Pt A), 75-89, 2015, Epub

  • Edifizi D, Schumacher B, Genome Instability in Development and Aging: Insights from Nucleotide Excision Repair in Humans, Biomolecules, 5(3), 1855-1869, 2015, Epub

  • Torgovnick A, Schumacher B., DNA repair mechanisms in cancer development and therapy., Front Genet., 6/157, 2015, Epub

  • Frommolt P, Schumacher B., Wormpath: searching for molecular interaction networks in Caenorhabditis elegans., Source Code Biol Med., 10(5), 2015, Epub

  • Nikoletopoulou V, Papandreou ME, Tavernarakis N, Autophagy in the physiology and pathology of the central nervous system, Cell Death Differ., 22(3), 398-407, 2015, Epub

  • Azzalin CM, Lingner J, Telomere functions grounding on TERRA firma., Trends Cell Biol., 25(1), 29-36, 2015, Epub

  • Kyriakakis E, Princz A, Tavernarakis N., Stress responses during ageing: molecular pathways regulating protein homeostasis., Methods Mol. Biol., 1292, 215-234, 2015, Epub

  • Aguado J., Rossiello F., d’Adda di Fagagna F., Detection of DNA damage response RNAs (DDRNAs) at dysfunctional telomeres, EMBO Conference:Telomeres, telomerase and disease, Brussels

  • Nkuipou-Kenfack E, Koeck T, Mischak H, Pich A, Schanstra JP, Zürbig P, Schumacher B., Proteome analysis in the assessment of ageing., Ageing Res Rev., 18, 74-85, 2014, Epub

  • Porro A, Feuerhahn S, Delafontaine J, Riethman H, Rougemont J, Lingner J., Functional characterization of the TERRA transcriptome at damaged telomeres, Nat Commun., 5, 5379, 2014, Epub

  • Marzia Fumagalli, Francesca Rossiello, Chiara Mondello, Fabrizio d'Adda di Fagagna, Stable Cellular Senescence Is Associated with Persistent DDR Activation, PLoS One., 9(10), e110969, 2014, Epub

  • Zemp I, Lingner J, The Shelterin Component TPP1 Is a Binding Partner and Substrate for the Deubiquitinating Enzyme USP7., J Biol Chem., 289(41), 28595-28606, 2014, Epub

  • Ermolaeva MA, Schumacher B, Insights from the worm: The C. elegans model for innate immunity., Semin Immunol., 26(4), 303-309, 2014, Epub

  • Rossiello F, Herbig U, Longhese MP, Fumagalli M, d'Adda di Fagagna F., Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing., Curr Opin Genet Dev., 26, 89-95, 2014, Epub

  • Nkuipou-Kenfack E, Duranton F, Gayrard N, Argiles A, Lundin U, Weinberger KM, Dakna M, Delles C, Mullen W, Husi H, Klein J, Koeck T, Zürbig P, and Mischak H, Assessment of metabolomic and proteomic biomarkers in detection and prognosis of progression of renal function in chronic kidney disease., PLoS One., 9(5), e96955, 2014, Epub

  • Piunti A, Rossi A, Cerutti A, Albert M, Jammula S, Scelfo A, Cedrone L, Fragola G, Olsson L, Koseki H, Testa G, Casola S, Helin K, d'Adda di Fagagna F, Pasini D., Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication, Nat Commun, 5, 3649, 2014, Epub

  • Behrens A, van Deursen JM, Rudolph KL, Schumacher B., Impact of genomic damage and ageing on stem cell function., Nature Cell Biol, 16(3), 201-207, 2014, Epub

  • M Ogrunc, R Di Micco, M Liontos, L Bombardelli, M Mione, M Fumagalli, V G Gorgoulis and F d'Adda di Fagagna, Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation., Cell Death Differ., 21(6), 998-1012, 2014, Epub

  • Porro, A, Feuerhahn, S, and Lingner, J, TERRA-reinforced association of LSD1 with MRE11 promotes processing of uncapped telomeres., Cell Rep., 6(4), 765-776, 2014, Epub

  • Ermolaeva MA, Schumacher B, Systemic DNA damage responses: organismal adaptations to genome instability., Trends Genet, 30(3), 95-102, 2014, Epub

  • Wolters S, Ermolaeva MA, Bickel JS, Fingerhut JM, Khanikar J, Chan RC, Schumacher B., Loss of Caenorhabditis elegans BRCA1 Promotes Genome Stability During Replication in smc-5 Mutants., Genetics, 196(4), 985-999, 2014, Epub

  • Rieckher M, Markaki M, Princz A, Tavernarakis N, A novel role for P bodies as regulators of stress responses and ageing in C. elegans., Aging, Metabolism, Pathogenesis, Stress, and Small RNAs in C. elegans, Wisconsin, United States. 2014

  • Majerska J, Lingner J, Unraveling the changes in telomere composition during senescence, immortalization, and tumorigenic conversion of normal human fibroblasts. EMBO Conference:Telomeres, telomerase and disease, Brussels., 2014

  • Edifizi D, Babu V, Castells-Roca L, Schumacher B, Role of DAF-16 in promoting DNA damage tolerance and stress resistance in C.elegans., 30th Ernst Klenk Symposium in Molecular Medecine, Center for Molecular Medecine Cologne (CMMC)., 2014

  • Grolimund, L, Aeby, E, Hamelin, R, Armand, F, Chiappe, D, Moniatte, M, Lingner, J, A quantitative telomeric chromatin isolation protocol identifies different telomeric states., Nat Commun., 4, 2848, 2013, Epub

  • Ermolaeva M, Schumacher B, The innate immune system as mediator of systemic DNA damage responses., Commun Integr Biol., 6(6), e26926, 2013, Epub

  • Pfeiffer, V, Crittin, J, Grolimund, L, Lingner, J, The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening., EMBO J., 23(21), 2861-2871, 2013, Epub

  • d'Adda di Fagagna F, A direct role for small non-coding RNAs in DNA damage response, Trends Cell Biol. , 24(3), 171-178, 2013, Epub

  • Chen, LY, Majerska, J, Lingner, J, Molecular basis of telomere syndrome caused by CTC1 mutations., Genes Dev., 27(19), 2099-2108, 2013, Epub

  • Redon, S, Zemp, I, and Lingner, J, A three-state model for the regulation of telomerase by TERRA and hnRNPA1., Nucleic Acids Res., 41(19), 9117-9128, 2013, Epub

  • Ermolaeva MA, Segref A, Dakhovnik A, Ou HL, Schneider JI, Utermöhlen O, Hoppe T, Schumacher B., DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance., Nature, 501(7467), 416-420, 2013, Epub

  • Schermer B, Bartels V, Frommolt P, Habermann B, Braun F, Schultze JL, Roodbergen M, Hoeijmakers JH, Schumacher B, Nürnberg P, Dollé ME, Benzing T, Müller RU, Kurschat CE., Transcriptional profiling reveals progeroid Ercc1-/Δ mice as a model system for glomerular ageing., BMC Genomics, 14, 559, 2013, Epub

  • Schneider L., Pellegatta S.,Favaro R., Federica Pisati, Paola Roncaglia, Giuseppe Testa, Silvia K. Nicolis, Gaetano Finocchiaro, Fabrizio d'Adda di Fagagna, DNA Damage in Mammalian Neural Stem Cells Leads to Astrocytic Differentiation Mediated by BMP2 Signaling through JAK-STAT, Stem Cell Reports, 1(2), 123-138, 2013, Epub

  • Wolters S, Schumacher B, Genome maintenance and transcription integrity in aging and disease., Front Genet., 4, 19, 2013, Epub

  • T. Sperka et al, Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction, Nature Cell Biol, 14(1), 73-79, 2011, Epub

  • S. G. Addinall et al, Quantitative Fitness Analysis Shows That NMD Proteins and Many Other Protein Complexes Suppress or Enhance Distinct Telomere Cap Defects, PLoS Genet. 7(4), e1001362, 2011, Epub

  • E. Kalay et al, CEP152 is a genome maintenance protein disrupted in Seckel syndrome, Nat Genet, 43(1), 23-26, 2011, Epub

  • J. M. Dewar, D. Lydall, Pif1- and Exo1-dependent nucleases coordinate checkpoint activation following telomere uncapping, The EMBO Journal, 29(23), 4020-4034, 2010, Epub

  • A. Porro, S. Feuerhahn, P. Reichenbach, J. Lingner, Molecular dissection of telomeric repeat-containing RNA biogenesis unveils the presence of distinct and multiple regulatory pathways, Mol Cell Biol 30(20), 4808-4817, 2010, Epub

  • H. Mischak et al, Recommendations for biomarker identification and qualification in clinical proteomics, Sci Transl Med, 2(46), 46ps42, 2010, Epub

  • Ngo HP, Lydall D, Survival and Growth of Yeast without Telomere Capping by Cdc13 in the Absence of Sgs1, Exo1, and Rad9, PLoS Genet. 6(8), e1001072, 2010, Epub

  • Artal-Sanz M, Tavernarakis N, Prohibitin couples diapause signaling to mitochondrial energy metabolism during ageing in Caenorhabditis elegans., Nature, 461(7265), 793-797, 2009, Epub

  • Y. Begus-Nahrmann et al, p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice, Nature Genetics, 41(10), 1138-1141, 2009, Epub

  • D. Seelow, M. Schuelke, F. Hildebrandt, P. Nurnberg, HomozygosityMapper--an interactive approach to homozygosity mapping, Nucleic Acids Res, 37, W293-599, 2009, Epub

  • S. Tzima, P. Victoratos, K. Kranidioti, M. Alexiou, G. Kollias, Myeloid heme oxygenase-1 regulates innate immunity and autoimmunity by modulating IFN-beta production, J Exp Med, 206(5), 1167-1179, 2009, Epub

  • Garinis GA et al, Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity, Nature Cell Biol, 11(5), 604-615, 2009, Epub

  • P.Zürbig et al, The human urinary proteome reveals high similarity between kidney aging and chronic kidney disease, Proteomics, 9(8), 2108-2117, 2009, Epub

  • F. Rutsch et al, Identification of a putative lysosomal cobalamin exporter altered in the cblF defect of vitamin B12 metabolism, Nat Genet, 41(2), 234-239, 2009, Epub

  • B. Luke, A. Panza, S. Redon, N. Iglesias, Z. Li, J. Lingner, The Rat1p 5' to 3' exonuclease degrades telomeric repeat-containing RNA and promotes telomere elongation in Saccharomyces cerevisiae, Mol Cell Biol 32(4), 465-477, 2008, Epub

  • R. Gareus et al, Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis, Cell Metab, 8(5), 372-383, 2008, Epub

  • M. A. Ermolaeva et al, Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses, Nat Immunol, 9(9), 1037-1046, 2008, Epub

  • Schumacher B et al., Delayed and accelerated aging share common longevity assurance mechanisms., PLoS Genet. 4(8), e1000161, 2008, Epub

  • H. Jiang et al, Proteins induced by telomere dysfunction and DNA damage represent biomarkers of human aging and disease, Proc Natl Acad Sci USA, 105(32), 11299-11304, 2008, Epub

  • Fabrizio d'Adda di Fagagna, Living on a break: cellular senescence as a DNA-damage response, Nature Reviews Cancer, 8(7), 512-522, 2008, Epub

  • C. M. Azzalin, P. Reichenbach, L. Khoriauli, E. Giulotto, J. Lingner, Telomeric repeat containing RNA and RNA surveillance factors at mammalian chromosome ends, Science, 318(5851), 798-801, 2007, Epub

  • S. Schaetzlein et al, Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice, Cell, 130(5), 863-877, 2007, Epub

  • P. Syntichaki, K. Troulinaki, N. Tavernarakis, eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans, Nature, 445(7130), 922-926, 2007, Epub

  • L. J. Niedernhofer et al., A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis., Nature, 444(7122), 1038-1043, 2006, Epub

  • R. Di Micco et al, Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication, Nature, 444(7119), 638-642, 2006, Epub

  • Schumacher B et al., Translational Repression of C. elegans p53 by GLD-1 regulates DNA damage induced apoptosis, Cell, 120, 357-368, 2005

  • F. d'Adda di Fagagna et al., A DNA damage checkpoint response in telomere-initiated senescence, Nature, 426, 194-198, 2003, Epub

  • P. Syntichaki, K. Xu, M. Driscoll, N. Tavernarakis, Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans, Nature, 419(6910), 939-944, 2002, Epub